产品名称
MUC20 Rabbit Polyclonal Antibody
基因名称
MUC20 KIAA1359 UNQ2782/PRO7170
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=200958
Human Swissprot No.
Q8N307
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N307
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=224116
Mouse Swissprot No.
Q8BUE7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BUE7/entry
特异性
This antibody detects endogenous levels of MUC20 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.
细胞定位
Secreted . Apical cell membrane . Basolateral cell membrane . Cell projection, microvillus membrane .
功能
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
