产品名称
C6orf134 Rabbit Polyclonal Antibody
基因名称
ATAT1 C6orf134 MEC17 Nbla00487
蛋白名称
Alpha-tubulin N-acetyltransferase (Alpha-TAT) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79969
Human Swissprot No.
Q5SQI0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5SQI0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=73242
Mouse Swissprot No.
Q8K341
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K341/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361789
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6MG11/entry
特异性
This antibody detects endogenous levels of C6orf134 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Membrane, clathrin-coated pit . Cell junction, focal adhesion . Cell projection, axon . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle .
功能
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
