产品名称
ANK3 Rabbit Polyclonal Antibody
蛋白名称
Ankyrin-3 (ANK-3) (Ankyrin-G)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=288
Human Swissprot No.
Q12955
Human Swissprot Link
https://www.uniprot.org/uniprot/Q12955
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11735
Mouse Swissprot No.
G5E8K5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/G5E8K5/entry
特异性
This antibody detects endogenous levels of ANK3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in brain, neurons, muscles and other tissues.
细胞定位
Cytoplasm, cytoskeleton . Cell projection, axon . Cell membrane, sarcolemma . Cell junction, synapse, postsynaptic cell membrane . Lysosome . Cell membrane, sarcolemma, T-tubule . In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes. .; [Isoform 5]: Cytoplasm, cytoskeleton . Golgi apparatus .
功能
In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption . ; [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.
