产品名称
DOC2A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8448
Human Swissprot No.
Q14183
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14183/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13446
Mouse Swissprot No.
Q7TNF0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TNF0
Rat Gene Link
https://www.uniprot.org/uniprot/65031
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P70611
免疫原
Synthesized peptide derived from human DOC2A AA range: 22-72
特异性
This antibody detects endogenous levels of DOC2A at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
组织表达
Predominantly expressed in brain. Also expressed in testis.
细胞定位
Lysosome . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein . Cell junction, synapse, synaptosome.
功能
domain:C2 domain 1 is involved in binding calcium and phospholipids.,function:May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in dynein-dependent intracellular vesicle transport. In vitro, binds calcium and phospholipids.,similarity:Contains 2 C2 domains.,subcellular location:Colocalizes to synaptic vesicles.,subunit:Interacts through its N-terminus with UNC13A. Interacts with cytoplasmic dynein light chain TCTEL1/TCTEX1.,tissue specificity:Predominantly expressed in brain. Also expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
