产品名称
DMRT1 Rabbit Polyclonal Antibody
蛋白名称
Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1761
Human Swissprot No.
Q9Y5R6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y5R6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50796
Mouse Swissprot No.
Q9QZ59
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZ59/entry
特异性
This antibody detects endogenous levels of DMRT1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Testis-specific. Expressed in prostate cancer (at protein level).
功能
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
