产品名称
SYT14 Rabbit Polyclonal Antibody
蛋白名称
Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NB59
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NB59/entry
Mouse Swissprot No.
Q7TN84
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TN84
免疫原
Synthesized peptide derived from part region of human protein
特异性
SYT14 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
synaptotagmin 14(SYT14) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011],
组织表达
Highly expressed in fetal and adult brain tissue.
细胞定位
Membrane ; Single-pass type III membrane protein . Localized in perinuclear and submembranous regions.
功能
function:May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subunit:Homodimer. Can also form heterodimers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
