产品名称
NELF Rabbit Polyclonal Antibody
蛋白名称
Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26012
Human Swissprot No.
Q6X4W1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6X4W1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56876
Mouse Swissprot No.
Q99NF2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99NF2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117536
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPI6/entry
特异性
This antibody detects endogenous levels of NELF at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney.
细胞定位
Nucleus . Nucleus envelope . Nucleus membrane . Nucleus matrix . Cytoplasm . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Cell membrane ; Peripheral membrane protein . Cell projection, dendrite . Cell junction, synapse . Cell junction, synapse, synaptosome . Cell junction, synapse, postsynaptic density . Membrane . Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium. Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in a importin-dependent manner (By similarity). .
功能
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
