产品名称
Cofilin 2 Rabbit Polyclonal Antibody
蛋白名称
Cofilin-2 (Cofilin, muscle isoform)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1073
Human Swissprot No.
Q9Y281
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y281
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12632
Mouse Swissprot No.
P45591
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P45591/entry
特异性
This antibody detects endogenous levels of Cofilin 2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
细胞定位
Nucleus matrix . Cytoplasm, cytoskeleton . Colocalizes with CSPR3 in the Z line of sarcomeres. .
功能
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 . It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).
