产品名称
BORIS Rabbit Polyclonal Antibody
蛋白名称
Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140690
Human Swissprot No.
Q8NI51
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NI51
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=664799
Mouse Swissprot No.
A2APF3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2APF3/entry
特异性
This antibody detects endogenous levels of BORIS at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Testis specific. Specifically expressed in primary spermatocytes.
功能
Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
