产品名称
SARS Rabbit Polyclonal Antibody
蛋白名称
Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6301
Human Swissprot No.
P49591
Human Swissprot Link
https://www.uniprot.org/uniprot/P49591
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20226
Mouse Swissprot No.
P26638
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P26638/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=266975
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P799/entry
特异性
This antibody detects endogenous levels of SARS at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. .
功能
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) . Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) . In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC . Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA .
