产品名称
FEM1C Rabbit Polyclonal Antibody
蛋白名称
Protein fem-1 homolog C (FEM1c) (FEM1-gamma)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56929
Human Swissprot No.
Q96JP0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96JP0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=240263
Mouse Swissprot No.
Q8CEF1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CEF1/entry
特异性
This antibody detects endogenous levels of FEM1C at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage.
功能
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation . The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding . Promotes ubiquitination and degradation of SLBP .
