产品名称
SVIL Rabbit Polyclonal Antibody
蛋白名称
Supervillin (Archvillin) (p205/p250)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O95425
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95425/entry
Mouse Swissprot No.
Q8K4L3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K4L3
免疫原
Synthesized peptide derived from part region of human protein
特异性
SVIL Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016],
组织表达
Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific.
细胞定位
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody . Cleavage furrow . Tightly associated with both actin filaments and plasma membranes.
功能
function:Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the villin/gelsolin family.,similarity:Contains 1 HP (headpiece) domain.,similarity:Contains 5 gelsolin-like repeats.,subcellular location:Tightly associated with both actin filaments and plasma membranes.,subunit:Binds to F-actin.,tissue specificity:Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 2 (archvillin) is muscle specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
