产品名称
Torsin A Rabbit Polyclonal Antibody
蛋白名称
Torsin-1A (Dystonia 1 protein) (Torsin family 1 member A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1861
Human Swissprot No.
O14656
Human Swissprot Link
https://www.uniprot.org/uniprot/O14656
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30931
Mouse Swissprot No.
Q9ER39
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ER39/entry
特异性
This antibody detects endogenous levels of Torsin A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Highest levels in kidney and liver. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also highly expressed in the spinal cord.
细胞定位
Endoplasmic reticulum lumen . Nucleus membrane ; Peripheral membrane protein . Cell projection, growth cone . Cytoplasmic vesicle membrane . Cytoplasmic vesicle, secretory vesicle . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytoskeleton. Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2. .
功能
Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.
