产品名称
PRICKLE3 Rabbit Polyclonal Antibody
蛋白名称
Prickle-like protein 3 (LIM domain only protein 6) (LMO-6) (Triple LIM domain protein 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4007
Human Swissprot No.
O43900
Human Swissprot Link
https://www.uniprot.org/uniprot/O43900
Mouse Swissprot No.
Q80VL3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80VL3/entry
特异性
This antibody detects endogenous levels of PRICKLE3 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion . Recruited by VANGL2 to anterior cell borders. This polarity is controlled by Wnt proteins (By similarity). WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity). .
功能
Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) .
