产品名称
TNNC1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7134
Human Swissprot No.
P63316
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P63316/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/21924
Mouse Swissprot No.
P19123
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P19123
免疫原
Synthesized peptide derived from human TNNC1 AA range: 57-107
特异性
This antibody detects endogenous levels of TNNC1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008],
细胞定位
nucleoplasm,mitochondrion,cytosol,troponin complex,actin cytoskeleton,contractile fiber,
功能
disease:Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,function:Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.,miscellaneous:Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.,similarity:Belongs to the troponin C family.,similarity:Contains 4 EF-hand domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
