产品名称
RASGRF2 Rabbit Polyclonal Antibody
蛋白名称
Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5924
Human Swissprot No.
O14827
Human Swissprot Link
https://www.uniprot.org/uniprot/O14827
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19418
Mouse Swissprot No.
P70392
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70392/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114513
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q99JE4/entry
特异性
This antibody detects endogenous levels of RASGRF2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).
细胞定位
Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). .
功能
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
