产品名称
ZNF385A Rabbit Polyclonal Antibody
基因名称
ZNF385A HZF RZF ZNF385
蛋白名称
Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25946
Human Swissprot No.
Q96PM9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96PM9
特异性
This antibody detects endogenous levels of ZNF385A at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed predominantly in the retina.
细胞定位
Cytoplasm . Nucleus, nucleolus . Cell projection, dendrite . Detected in dendrites of Purkinje cells and hippocampal neurons. .
功能
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.
