产品名称
RRP1B Rabbit Polyclonal Antibody
蛋白名称
Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23076
Human Swissprot No.
Q14684
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14684
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72462
Mouse Swissprot No.
Q91YK2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YK2/entry
特异性
This antibody detects endogenous levels of RRP1B at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleolus . Nucleus, nucleoplasm . Chromosome . Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015). .; Nucleus, nucleoplasm . (Microbial infection) Following infection by influenza A virus, partially translocates from the nucleolus to the nucleoplasm. .
功能
Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 . Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus . Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure . ; (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.
