产品名称
KCNK18 Rabbit Polyclonal Antibody
蛋白名称
Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=338567
Human Swissprot No.
Q7Z418
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7Z418
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=332396
Mouse Swissprot No.
Q6VV64
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6VV64/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=445371
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6Q1P3/entry
特异性
This antibody detects endogenous levels of KCNK18 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).
