产品名称
H2AFY Rabbit Polyclonal Antibody
蛋白名称
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9555
Human Swissprot No.
O75367
Human Swissprot Link
https://www.uniprot.org/uniprot/O75367
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26914
Mouse Swissprot No.
Q9QZQ8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZQ8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29384
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q02874/entry
特异性
This antibody detects endogenous levels of H2AFY at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Chromosome . Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. .
功能
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation . Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes . Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin . ; [Isoform 1]: Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation . Increases the expression of genes involved in redox metabolism, including SOD3 . ; [Isoform 2]: Represses SOD3 gene expression.
