产品名称
NPL Rabbit Polyclonal Antibody
蛋白名称
N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80896
Human Swissprot No.
Q9BXD5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BXD5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74091
Mouse Swissprot No.
Q9DCJ9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DCJ9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304860
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q66H59/entry
特异性
This antibody detects endogenous levels of NPL at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.
功能
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate . It prevents sialic acids from being recycled and returning to the cell surface . Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway . Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable).
