产品名称
WRNIP1 Rabbit Polyclonal Antibody
蛋白名称
ATPase WRNIP1 (Werner helicase-interacting protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56897
Human Swissprot No.
Q96S55
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96S55
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=78903
Mouse Swissprot No.
Q91XU0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91XU0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=282835
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CG07/entry
特异性
This antibody detects endogenous levels of WRNIP1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
细胞定位
Nucleus . Cytoplasm . Colocalizes with WRN in granular structures in the nucleus. .
功能
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.
