产品名称
TRIM39 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase TRIM39 (EC 6.3.2.-) (RING finger protein 23) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56658
Human Swissprot No.
Q9HCM9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HCM9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79263
Mouse Swissprot No.
Q9ESN2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ESN2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=309591
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6MFZ5/entry
特异性
This antibody detects endogenous levels of TRIM39 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
细胞定位
[Isoform 1]: Cytoplasm, cytosol . Mitochondrion . Nucleus . Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. .; [Isoform 2]: Nucleus . Colocalizes with CDKN1A in the nucleus. .
功能
[Isoform 1]: E3 ubiquitin-protein ligase . May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 . Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . ; [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner .
