产品名称
TIPIN Rabbit Polyclonal Antibody
蛋白名称
TIMELESS-interacting protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54962
Human Swissprot No.
Q9BVW5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BVW5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66131
Mouse Swissprot No.
Q91WA1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91WA1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363076
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4QR88/entry
特异性
This antibody detects endogenous levels of TIPIN at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus .
功能
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
