产品名称
TGS1 Rabbit Polyclonal Antibody
基因名称
TGS1 HCA137 NCOA6IP PIMT
蛋白名称
Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N2 methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=96764
Human Swissprot No.
Q96RS0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96RS0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116940
Mouse Swissprot No.
Q923W1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q923W1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=312947
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P85107/entry
特异性
This antibody detects endogenous levels of TGS1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.
细胞定位
Cytoplasm . Nucleus, Cajal body . Nucleus, nucleolus . A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network. .
功能
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
