产品名称
TESPA1 Rabbit Polyclonal Antibody
基因名称
TESPA1 KIAA0748 HSPC257
蛋白名称
Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9840
Human Swissprot No.
A2RU30
Human Swissprot Link
https://www.uniprot.org/uniprot/A2RU30
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67596
Mouse Swissprot No.
Q3U132
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U132/entry
特异性
This antibody detects endogenous levels of TESPA1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Endoplasmic reticulum membrane . May localize to mitochondria-associated endoplasmic reticulum membrane (MAM). .
功能
Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
