产品名称
SPRY3 Rabbit Polyclonal Antibody
蛋白名称
Protein sprouty homolog 3 (Spry-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10251
Human Swissprot No.
O43610
Human Swissprot Link
https://www.uniprot.org/uniprot/O43610
特异性
This antibody detects endogenous levels of SPRY3 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed; particularly in the fetal tissues. Expressed in the brain with expression the highest in Purkinje cells in the cerebellum (at protein level) (PubMed:26089202). Expressed in the myocardium of the heart (PubMed:30878395).
功能
Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation . May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis .
