产品名称
SNX18 Rabbit Polyclonal Antibody
基因名称
SNX18 SH3PXD3B SNAG1
蛋白名称
Sorting nexin-18 (SH3 and PX domain-containing protein 3B) (Sorting nexin-associated Golgi protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=112574
Human Swissprot No.
Q96RF0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96RF0
Mouse Swissprot No.
Q91ZR2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91ZR2/entry
特异性
This antibody detects endogenous levels of SNX18 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endomembrane system ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Localized at sites of endocytosis at the cell membrane (PubMed:18411244). Detected on newly formed macropinosomes (PubMed:21048941). Partially colocalized with clathrin and dynamin at the cell membrane (PubMed:20427313). Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (PubMed:18411244). .
功能
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis . Required for efficient progress through mitosis and cytokinesis . Required for normal formation of the cleavage furrow at the end of mitosis . Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis . Plays a role in macropinocytosis . Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation . Stimulates the GTPase activity of DNM2 . Promotes DNM2 location at the plasma membrane . Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A .
