产品名称
RPUSD4 Rabbit Polyclonal Antibody
蛋白名称
RNA pseudouridylate synthase domain-containing protein 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84881
Human Swissprot No.
Q96CM3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96CM3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71989
Mouse Swissprot No.
Q9CWX4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CWX4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315550
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4QQT0/entry
特异性
This antibody detects endogenous levels of RPUSD4 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Mitochondrion matrix . Nucleus . Cytoplasm . Mainly localizes to mitochondrion (PubMed:23435261, PubMed:27974379, PubMed:28082677). Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:27974379, PubMed:28082677). Also found in nucleus and cytoplasm (PubMed:23435261). .
功能
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates . Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) . This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation . Acts on position 39 in mitochondrial tRNA(Phe) . Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions . Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing .
