产品名称
Reticulocalbin 3 Rabbit Polyclonal Antibody
蛋白名称
Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57333
Human Swissprot No.
Q96D15
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96D15
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=52377
Mouse Swissprot No.
Q8BH97
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BH97/entry
特异性
This antibody detects endogenous levels of Reticulocalbin 3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum lumen .
功能
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum . Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens . This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion .
