产品名称
RBM22 Rabbit Polyclonal Antibody
蛋白名称
Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55696
Human Swissprot No.
Q9NW64
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NW64
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66810
Mouse Swissprot No.
Q8BHS3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BHS3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=307410
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4V7D7/entry
特异性
This antibody detects endogenous levels of RBM22 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Cytoplasm . Nearly exclusively nuclear. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol. .
功能
Required for pre-mRNA splicing as component of the activated spliceosome . Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
