产品名称
PSRC1 Rabbit Polyclonal Antibody
蛋白名称
Proline/serine-rich coiled-coil protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84722
Human Swissprot No.
Q6PGN9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6PGN9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56742
Mouse Swissprot No.
Q9D0P7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D0P7/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=691380
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3KR66/entry
特异性
This antibody detects endogenous levels of PSRC1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
功能
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
