产品名称
PAG1 Rabbit Polyclonal Antibody
蛋白名称
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55824
Human Swissprot No.
Q9NWQ8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NWQ8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94212
Mouse Swissprot No.
Q3U1F9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U1F9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64019
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JM80/entry
特异性
This antibody detects endogenous levels of PAG1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
细胞定位
Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.
功能
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
