产品名称
MAML1 Rabbit Polyclonal Antibody
蛋白名称
Mastermind-like protein 1 (Mam-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9794
Human Swissprot No.
Q92585
Human Swissprot Link
https://www.uniprot.org/uniprot/Q92585
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=103806
Mouse Swissprot No.
Q6T264
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6T264/entry
特异性
This antibody detects endogenous levels of MAML1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
细胞定位
Nucleus speckle . Nuclear, in a punctate manner.
功能
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
