产品名称
SNX5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y5X3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y5X3/entry
Mouse Swissprot No.
Q9D8U8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D8U8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941B1H267
免疫原
Synthesized peptide derived from part region of human protein
特异性
SNX5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013],
组织表达
Brain,Lymph,Ovarian carcinoma,Placenta,Synovial membrane,
细胞定位
Endosome . Early endosome . Early endosome membrane ; Peripheral membrane protein; Cytoplasmic side. Cell membrane ; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation. .
功能
function:May be involved in several stages of intracellular trafficking.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
