产品名称
LARGE Rabbit Polyclonal Antibody
基因名称
LARGE KIAA0609 LARGE1
蛋白名称
Glycosyltransferase-like protein LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9215
Human Swissprot No.
O95461
Human Swissprot Link
https://www.uniprot.org/uniprot/O95461
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16795
Mouse Swissprot No.
Q9Z1M7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1M7/entry
特异性
This antibody detects endogenous levels of LARGE at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Highest expression in heart, brain and skeletal muscle.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
功能
Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity . Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide . Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer . Plays a key role in skeletal muscle function and regeneration (By similarity).
