产品名称
INTU Rabbit Polyclonal Antibody
基因名称
INTU KIAA1284 PDZD6 PDZK6
蛋白名称
Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27152
Human Swissprot No.
Q9ULD6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9ULD6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=380614
Mouse Swissprot No.
Q059U7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q059U7/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361938
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D4ACE5/entry
特异性
This antibody detects endogenous levels of INTU at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cell surface . Cytoplasm, cytoskeleton, cilium basal body . Enriched at the apical surface in ciliated cells. .
功能
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies .
