产品名称
FAM126A Rabbit Polyclonal Antibody
蛋白名称
Hyccin (Down-regulated by CTNNB1 protein A) (Protein FAM126A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84668
Human Swissprot No.
Q9BYI3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BYI3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84652
Mouse Swissprot No.
Q6P9N1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P9N1/entry
特异性
This antibody detects endogenous levels of FAM126A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Highest levels in heart, brain, placenta, spleen and testis.
细胞定位
Cytoplasm, cytosol . Cell membrane . Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex. .
功能
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane . The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis . FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P . Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system . May also have a role in the beta-catenin/Lef signaling pathway (Probable).
