产品名称
GTR8 Rabbit Polyclonal Antibody
蛋白名称
Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NY64
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NY64/entry
Mouse Swissprot No.
Q9JIF3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JIF3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JJZ1
免疫原
Synthesized peptide derived from human protein . at AA range: 230-310
特异性
GTR8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012],
组织表达
Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.
细胞定位
Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. .
功能
function:Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose.,induction:In testis, down-regulated by estrogen.,similarity:Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.,subcellular location:Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration.,tissue specificity:Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
