产品名称
ANKLE2 Rabbit Polyclonal Antibody
基因名称
ANKLE2 KIAA0692 LEM4
蛋白名称
Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23141
Human Swissprot No.
Q86XL3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86XL3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71782
Mouse Swissprot No.
Q6P1H6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P1H6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360829
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TP65/entry
特异性
This antibody detects endogenous levels of ANKLE2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
功能
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit . Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly . May regulate nuclear localization of VRK1 in non-dividing cells . It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex . Involved in brain development .
