产品名称
S12A2 Rabbit Polyclonal Antibody
蛋白名称
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P55011
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P55011/entry
Mouse Swissprot No.
P55012
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P55012
免疫原
Synthesized peptide derived from part region of human protein
特异性
S12A2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
组织表达
Expressed in many tissues.
细胞定位
Basolateral cell membrane ; Multi-pass membrane protein .
信号通路
Vibrio cholerae infection;
功能
function:Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SLC12A transporter family.,tissue specificity:Expressed in many tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
