产品名称
PELI2 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 6.3.2.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57161
Human Swissprot No.
Q9HAT8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HAT8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93834
Mouse Swissprot No.
Q8BST6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BST6/entry
特异性
This antibody detects endogenous levels of PELI2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
