产品名称
PDZD3 Rabbit Polyclonal Antibody
基因名称
PDZD3 IKEPP NHERF4 PDZK2 DLNB27
蛋白名称
Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79849
Human Swissprot No.
Q86UT5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86UT5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170761
Mouse Swissprot No.
Q99MJ6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99MJ6/entry
特异性
This antibody detects endogenous levels of PDZD3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.
细胞定位
Cell membrane ; Peripheral membrane protein . Cytoplasm . Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451). .
功能
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation . Stimulates SLC9A3 activity in the presence of elevated calcium ions .
