产品名称
ZNF207 Rabbit Polyclonal Antibody
蛋白名称
Zinc finger protein 207
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7756
Human Swissprot No.
O43670
Human Swissprot Link
https://www.uniprot.org/uniprot/O43670
特异性
This antibody detects endogenous levels of ZNF207 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. .
功能
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly . ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks . Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 . Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome .
