产品名称
TFAP2E Rabbit Polyclonal Antibody
蛋白名称
Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=339488
Human Swissprot No.
Q6VUC0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6VUC0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=332937
Mouse Swissprot No.
Q6VUP9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6VUP9/entry
特异性
This antibody detects endogenous levels of TFAP2E at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line.
功能
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).
