产品名称
NPT2A Rabbit Polyclonal Antibody
基因名称
SLC34A1 NPT2 SLC17A2
蛋白名称
Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-3) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q06495
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q06495/entry
Mouse Swissprot No.
Q60825
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60825
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q06496
免疫原
Synthesized peptide derived from human protein . at AA range: 260-340
特异性
NPT2A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009],
细胞定位
Apical cell membrane ; Multi-pass membrane protein .
功能
disease:Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1) [MIM:612286]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).,function:May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.,similarity:Belongs to the SLC34A transporter family.,subunit:Interacts via its C-terminal region with PDZK2.,tissue specificity:Kidney and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
