产品名称
SH3RF2 Rabbit Polyclonal Antibody
基因名称
SH3RF2 PPP1R39 RNF158
蛋白名称
Putative E3 ubiquitin-protein ligase SH3RF2 (EC 6.3.2.-) (Heart protein phosphatase 1-binding protein) (HEPP1) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (SH3 domain-containing RING finger protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=153769
Human Swissprot No.
Q8TEC5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8TEC5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=269016
Mouse Swissprot No.
Q8BZT2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BZT2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=307472
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q498M5/entry
特异性
This antibody detects endogenous levels of SH3RF2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level). Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.
功能
Has E3 ubiquitin-protein ligase activity . Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation . Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation . Inhibits PPP1CA phosphatase activity .
