产品名称
SEC24D Rabbit Polyclonal Antibody
蛋白名称
Protein transport protein Sec24D (SEC24-related protein D)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9871
Human Swissprot No.
O94855
Human Swissprot Link
https://www.uniprot.org/uniprot/O94855
特异性
This antibody detects endogenous levels of SEC24D at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.
细胞定位
Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol .
功能
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex . Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B . May more specifically package GPI-anchored proteins through the cargo receptor TMED10 . May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 .
