产品名称
RS1 Rabbit Polyclonal Antibody
蛋白名称
Retinoschisin (X-linked juvenile retinoschisis protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6247
Human Swissprot No.
O15537
Human Swissprot Link
https://www.uniprot.org/uniprot/O15537
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20147
Mouse Swissprot No.
Q9Z1L4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1L4/entry
特异性
This antibody detects endogenous levels of RS1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Restricted to the retina (at protein level) (PubMed:10915776). Detected in the inner segment of the photoreceptors, the inner nuclear layer, the inner plexiform layer and the ganglion cell layer (at protein level). At the macula, expressed in both the outer and inner nuclear layers and in the inner plexiform layer (at protein level) (PubMed:10915776). Detected in retina (PubMed:9326935). Detected only within the photoreceptor cell layer, most prominently within the inner segments of the photoreceptors (PubMed:10915776). Undetectable in the inner plexiform layers and the inner nuclear layer (PubMed:10915776).
细胞定位
Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Binds to phosphatidylserine-containing lipid membranes and embeds itself partially into the lipid bilayer. Lipid-binding requires the presence of Ca(2+) ions. .
功能
Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells . Required for normal structure and function of the retina .
