产品名称
RANGRF Rabbit Polyclonal Antibody
基因名称
RANGRF MOG1 RANGNRF HSPC165 HSPC236 MDS5
蛋白名称
Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29098
Human Swissprot No.
Q9HD47
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HD47
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57785
Mouse Swissprot No.
Q9JIB0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JIB0/entry
特异性
This antibody detects endogenous levels of RANGRF at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375).
细胞定位
Nucleus . Cytoplasm, perinuclear region . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . May shuttle between the nucleus and cytoplasm. .
功能
May regulate the intracellular trafficking of RAN . Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 . Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics . Enhances the expression of SCN5A at the cell membrane in cardiomyocytes .
